Tuning NOTCH

Tuning NOTCH

The emergence of multi-cellular organs and their organization into complex body plans is a major cornerstone concerning origin of life on Earth. This requires that the fundamental unit of life, namely the cell, must communicate, coordinate and organize. Cell communication mediated by signal transduction pathways is essential for the development and functioning of any organism. About 20 differen...

The spatial tuning of color and luminance peripheral vision measured with notch filtered noise masking

We have measured the spatial bandwidths of the bandpass red-green chromatic and luminance mechanisms at four locations in the nasal visual field (0, 10, 20 and 30 degrees) using a method of notch filtered noise masking which effectively removes the artifact of off-frequency looking for our stimuli. Detection thresholds were measured for luminance or isoluminant red-green Gaussian enveloped test...

Notch

The crux of development is that different cells need to be instructed to follow different developmental decisions. This involves signalling between cells so that each cell knows what its neighbour is doing. The Notch protein is pivotal for communication between cells during development and if Notch activity is perturbed, a cell may no longer be aware of which fate it should adopt. One consequen...

NOTCH 2 ( Notch homolog 2 ( Drosophila ) )

Retrograde Tuning of Tuning

One way to localize sounds is to measure differences in sound intensity at the two ears. This comparison is made in the lateral superior olive, where signals from both ears converge. Magnusson et al. in this issue of Neuron show that dendritic GABA release can regulate this comparison, which may allow animals localizing sounds to adapt to listening conditions.